Biogenesis of viral factories

Infectious diseases continue to be the main cause of death worldwide. In particular, RNA viruses are devastating pathogens for humans, animals and plants. We are studying the replication factories assembled by several RNA viruses which are important human pathogens such as Bunyaviruses, Reoviruses and Infuenza viruses.

RNA viruses replicate their genomes on intracelIular membranes. Viruses recruit cell organelles and numerous viral and cellular factors to build their replication platforms also known as “viral factories”. Due to the complex interactions detected in these structures, viral factories could be considered as the actual living state of viruses. In the CSL we are searching for the key factors involved in the biogenesis of viral factories to understand how viruses manipulate cell organization and build new organelles. Our goal is to identify the structures that support virus replication, morphogenesis and egress to reveal potential targets for new antivirals.

Fernández de Castro, Tenorio & Risco., Current Opinion in Virology 2016; Fernández de Castro et al., mBio 2014; Risco et al., Annual Review of Virology, 2014; Fernández de Castro & Risco, Future Virology 2014.

MinecoNihcamCNBCSICSevero Ochoa